You can also phone us on +1 (832) 358-3308 or email from trough-based dosing to AUC-based dosing for vancomycin has numerous clinical and operational benefits. See how easy DoseMeRx is to operate and integrate into your workday. The previous 2009 vancomycin consensus guidelines recommend trough monitoring as a surrogate marker for the target area under the curve over 24 hours to minimum inhibitory concentration (AUC/MIC).
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Recent clinical data on vancomycin pharmacokinetics and pharmacodynamics suggest a reevaluation of current dosing and monitoring recommendations.The CPS calculated a new vancomycin regimen which was predicted to attain a 24-hour vancomycin AUC level of 400-600 mg*hr/L according to a Microsoft® Excel®-based calculator using first-orderDose: 15-20 mg/kg/dose IV q8-12h x7 days Info: for inpatient tx refer to IDSA guidelines consider start 20-35 mg/kg/dose IV x1 in seriously ill pts, max 3 g/dose use ABW to calculate dose adjust dose based on serum levels consider 20-25 mg/kg/dose IV x1 then 10-15 mg/kg/dose IV q12h in obese pts using ABW, consider 10-12.5 mg/kg/dose IV. Monitoring to estimate the vancomycin AUC, was performed by attaining vancomycin peak and trough levels. Vancomycin Pulsed Infusion Vancomycin Continuous Infusion CrCL (ml/min) Dose Interval Creat CL (ml/min) Dose / 12 h 110 Doses Ideal body weight (kg) Creatinine CL (ml/min) SumAnybody use AUC/MIC for Vanco dosing at their hospital? How do you calculate the dose? Online calc, homegrown Excel calc? Let me know! Looking to … AUC goal of 400-600 mg*hr/L after the initial dose. Authors Raj Desai and Steven Smith evaluated data for patients with stable hypertension and depression to determine whether the initiation of serotonin norepinephrine reuptake inhibitors had a similar risk of antihypertensive treatment intensification and major adverse cardiovascular events compared to initiation of SSRIs.Daily doses of 15-20 mg/kg (using actual bodyweight) given every 8-12 h recommended for most patients with normal renal function and when organism MIC is 400 is not.
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Replacement dose calculation: The replacement dose replaces that which is removed during dialysis plus the amount lost between dialysis sessions. The AUC calculated is greater than 600 mg*hr/L per 24 hours for troughs of 25 mcg/ml. The AUC calculated is greater than 500 mg*hr/L per 24 hours with troughs of 20 mg/L. Authors: Richard H Drew, PharmD, MS, FCCP, FIDP. Vancomycin: Parenteral dosing, monitoring, and adverse effects in adults.
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Examples and templates of educational materials for training providers and nursing teams.Calculator: Creatinine clearance estimate by Cockcroft-Gault equation in adults and older adolescents (age ≥16 years) (conventional units)*. Customizable vancomycin dosing calculator with an automatically generated patient progress note. Toolkit Features: Template guideline for vancomycin dosing with highlighted areas to customize to your local facility. X2 The AUC calculated is greater than 500 mg*hr/L per 24 hours with troughs of 20 mg/L.